Bioinformatics
Edith Cowan University
About the Project Project overview: GLP-1/GIP dual agonists such as tirzepatide (Mounjaro) have transformed the treatment of obesity, type 2 diabetes and cardiometabolic disease. However, gastrointestinal side effects remain a leading cause of treatment discontinuation, and we still know remarkably little about what these therapies do to the gut itself.
- Location
- Joondalup, Australia, Australia
- Deadline
- 29 September 2026
- Funding
- Funded PhD Project (Students Worldwide)
Bioinformatics
University of Edinburgh
About the Project The problem Infertility affects roughly 1 in 7 couples, and in approximately half of these cases the cause lies with the male partner. Despite this, research into the genetic underpinnings of male infertility lags behind other fields, with only a small number of genes linked to male infertility having been identified. Severe male infertility, by definition, cannot be passed from father to son.
- Location
- Edinburgh, United Kingdom, United Kingdom
- Deadline
- 30 September 2026
- Funding
- Funded PhD Project (UK Students Only)
Bioinformatics
University of Santiago de Compostela
About the Project EUROPE: 15 PhD positions in the MSCA Doctoral Network DECODES: Deciphering the Splicing Code in Human Disease Grant Agreement No. 101312753 Alternative splicing (AS) is a fundamental post-transcriptional mechanism that enables a single gene to generate multiple protein isoforms, dramatically expanding proteomic diversity.
- Location
- Santiago de Compostela, Spain, Spain
- Deadline
- 30 September 2026
- Funding
- Funded PhD Project (Students Worldwide)
Bioinformatics
University of Glasgow
About the Project To apply, please click institution website. Background Emerging and re-emerging viruses continue to pose major threats to global health. Wastewater surveillance offers a unique opportunity to monitor viral circulation at the population level, providing early warning of outbreaks and the emergence of novel pathogens or variants.
- Location
- Glasgow, United Kingdom, United Kingdom
- Deadline
- 8 October 2026
- Funding
- Funded PhD Project (Students Worldwide)
Bioinformatics
University of Glasgow
About the Project Background The threat of a high-impact respiratory pandemic is growing, underscoring the urgent need for advanced surveillance systems. This project proposes the development of a pathogen-agnostic, AI-driven approach to respiratory syndromic surveillance by integrating clinical, laboratory (including genomic), and radiological data.
- Location
- Glasgow, United Kingdom, United Kingdom
- Deadline
- 8 October 2026
- Funding
- Funded PhD Project (Students Worldwide)
Bioinformatics
University of Cambridge
About the Project Fully-funded PhD studentship: Single-cell spatial multi-omics for cancer biology Reference: SW51030 Supervisor: Dr Guiping Wang Department/location : Cancer Research UK Cambridge Institute Deadline for application : 16 th October 2026 Course start date: 1 st October 2027 Overview Dr Guiping Wang wishes to recruit a student to work on the project entitled: “Single-cell spatial multi-omics for cancer biology”.
- Location
- Cambridge, United Kingdom
- Deadline
- 16 October 2026
- Funding
- UK Students, EU Students, International Students; Not Specified
Bioinformatics
University of Cambridge
About the Project Fully-funded PhD studentship: Understanding the identity and function of tumour-initiating states Reference: SW51026 Supervisor: ProfMasashi Narita Department/location : Cancer Research UK Cambridge Institute Deadline for application : 16 th October 2026 Course start date: 1 st October 2027 Overview Prof Masashi Narita wishes to recruit a student to work on the project entitled: “Understanding the identity and function of tumour-initiating states”.
- Location
- Cambridge, United Kingdom
- Deadline
- 16 October 2026
- Funding
- UK Students, EU Students, International Students; Not Specified
Bioinformatics
Cardiff University
About the Project Prostate cancer remains a leading cause of cancer mortality, particularly in metastatic disease where treatment options are limited. This project seeks to investigate the role of CD200, an immune checkpoint protein enriched in prostate cancer stem cells, in promoting tumour growth and immune evasion.
- Location
- Cardiff, United Kingdom, United Kingdom
- Deadline
- 21 October 2026
- Funding
- Competition Funded PhD Project (Students Worldwide)
Bioinformatics
Cardiff University
About the Project How do glioblastoma stem cells evade therapy and drive tumour recurrence? This project will address this question by investigating how FGF2-FGFR1 signalling regulates protein homeostasis in these highly aggressive cells. Using patient-derived models, multi-OMICs datasets, proteomics and functional laboratory assays, you will identify novel molecular mechanisms underlying stemness and treatment resistance.
- Location
- Cardiff, United Kingdom, United Kingdom
- Deadline
- 21 October 2026
- Funding
- Competition Funded PhD Project (Students Worldwide)
Bioinformatics
University of Bristol
About the Project Life on Earth is subordinate to periodic alterations in the environment, with most notable changes seen from day to night. To adapt to these cyclic changes, living organisms evolved endogenous 24h timekeeping mechanisms named circadian clocks.
- Location
- Bristol, United Kingdom, United Kingdom
- Deadline
- 21 October 2026
- Funding
- Competition Funded PhD Project (Students Worldwide)
Bioinformatics
University of Bath
About the Project This project is one of several in competition for funding from the GW4 BioMed3 MRC Doctoral Landscape Programme (DLP), which is offering up to 17 studentships for entry in September 2026. The partnership brings together the Universities of Bath, Bristol, Cardiff and Exeter to develop the next generation of biomedical researchers.
- Location
- Bath, United Kingdom, United Kingdom
- Deadline
- 21 October 2026
- Funding
- Competition Funded PhD Project (Students Worldwide)
Bioinformatics
University of Bath
About the Project This project is one of several in competition for funding from the GW4 BioMed3 MRC Doctoral Landscape Programme (DLP), which is offering up to 17 studentships for entry in September 2026. The partnership brings together the Universities of Bath, Bristol, Cardiff and Exeter to develop the next generation of biomedical researchers.
- Location
- Bath, United Kingdom, United Kingdom
- Deadline
- 21 October 2026
- Funding
- Competition Funded PhD Project (Students Worldwide)
Bioinformatics
The James Hutton Institute
About the Project Background To effectively protect natural habitats and biodiversity, accurate and up-to-date information is required on species and ecosystems to allow data driven evidence-based strategies for managing habitats and conserving species. Peatlands are a globally scarce yet highly valuable habitat in terms of carbon storage and biodiversity. Scotland consists of more than 20% peatland and stores approximately 1620 Mt of carbon.
- Location
- Dundee, United Kingdom, United Kingdom
- Deadline
- 23 October 2026
- Funding
- Competition Funded PhD Project (UK Students Only)
Bioinformatics
Centre for Genomic Regulation (CRG)
About the Project Our group aims to 'decode' the molecular rules by which sensor proteins can monitor highly diverse and specific environmental chemicals. To this end, we combine: Large-scale mutagenesis and functional data generation AI-enhanced evolutionary modeling Engineering of chemically inducible protein folds Who are we looking for?
- Location
- Barcelona, Spain, Spain
- Deadline
- 21 November 2026
- Funding
- Funded PhD Project (Students Worldwide)
Bioinformatics
University of Oxford
About the Project Are you interested in understanding how the spatial arrangement of cells shapes tissue inflammation? The immune system functions within highly organised tissue environments, where interactions between immune, stromal and structural cells are essential for maintaining health.
- Location
- Oxford, United Kingdom, United Kingdom
- Deadline
- 1 December 2026
- Funding
- Funded PhD Project (Students Worldwide)
Bioinformatics
University of Oxford
About the Project A major challenge in cancer is how to selectively and permanently disrupt the cancer cell yet leave normal functioning cells intact. The two main approaches are either to exploit the cancer specific genomic nucleotide and structural variants for lethality dependencies or to modify the immune system to destroy cancer cells via cell surface antigens and MHC presentation of ‘non-self’ antigens.
- Location
- Oxford, United Kingdom, United Kingdom
- Deadline
- 1 December 2026
- Funding
- Competition Funded PhD Project (Students Worldwide)
Bioinformatics
University of Oxford
About the Project Every human egg and sperm carries a unique genetic sequence. This diversity is essential for evolution, but it arises through DNA damage and repair processes that also threaten genome integrity. Our research seeks to understand how the genomes of eggs and sperm are generated, and how the molecular processes that shape them create genetic variation while preserving genome stability.
- Location
- Oxford, United Kingdom, United Kingdom
- Deadline
- 1 December 2026
- Funding
- Competition Funded PhD Project (Students Worldwide)
Bioinformatics
Medical Research Council (Cambridge)
About the Project The nervous system provides a wide range of signals to immune cells residing in peripheral tissues such as the lung, the salivary glands, the gut or the female reproductive tract. These neuronal cues are critical for immune homeostasis and modulation, and for boosting or curbing immune responses against viruses and other pathogens.
- Location
- Cambridge, United Kingdom, United Kingdom
- Deadline
- 8 December 2026
- Funding
- Competition Funded PhD Project (Students Worldwide)
Bioinformatics
University of Sheffield
About the Project Background Typhoid toxin is a DNase-like virulence factor of the human pathogen Salmonella Javiana, which intoxicates cells throughout the microenvironment. We discovered that the toxin induces DNA damage responses in cultured cells that activates a senescence tumour suppressor mechanism ( https://doi.org/10.1038/s41467-019-12064-1 ).
- Location
- Sheffield, United Kingdom, United Kingdom
- Deadline
- 31 December 2026
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Liverpool
About the Project IMPDH2 is a critical enzyme responsible for the rate limiting step of purine nucleotide biosynthesis. In naïve pluripotent stem cells, it forms large rod-ring structures (RRs) which are hypothesised to control the enzyme’s output when the pool of guanine nucleotides is in high demand. However, whether IMPDH2 interacts with other proteins in these structures is not well defined, and neither is their function during early embryogenesis.
- Location
- Liverpool, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Salford
About the Project Join us at the University of Salford to help shape the future of quantum technologies. Quantum Technologies (QTs) underpin many of the innovations that define modern life. The first generation of QTs gave us lasers, transistors, and the foundations of modern electronics. Today, the field is undergoing a revolution, seeking to harness more complex quantum effects including superposition, entanglement and quantum correlations.
- Location
- Manchester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of York
About the Project Lead supervisor: Prof Dawn Coverley Co-supervisors: Dr Andrew Mason The student will be registered with the Department of Biology Inside the mammalian cell nucleus DNA and associated proteins are spatially organised and differentially compacted, so that some genes are accessible and some are not.
- Location
- York, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Sheffield
About the Project Pluripotent stem cells (PSCs) are defined by their capacity for self-renewal and differentiation, making them an attractive platform for modelling human tissue formation in vitro. However, generating scalable, uniform differentiated cell types from PSCs remains challenging because of the limited control we have over the cellular environment.
- Location
- Sheffield, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
Kingston University
About the Project Type II (T2DM) is a chronic, multifactorial disease resulting in severe complications that lead to increased morbidity and even death. Due to the multifactorial pathology of the disease the interventions to treat T2DM and prevent complications may include lifestyle interventions, oral pharmacotherapy and self-injection with insulin.
- Location
- London, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of York
About the Project Lead supervisor: Dr Andrew Mason Co-supervisors: Dr Simon Baker The student will be registered with the Department of Biology Project Overview Muscle-invasive bladder cancer is a diverse disease where machine learning methods have so far failed to deliver clinically actionable subgroups.
- Location
- York, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Portsmouth
About the Project Applications are invited for a self-funded, 3 year full-time or 6 year part-time PhD project. The PhD will be based in the School of Medicine, Pharmacy and Biomedical Sciences and will be supervised by Dr Gavin Fullstone .
- Location
- Portsmouth, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Salford
About the Project Malaria is the most devastating vector borne disease worldwide. The World Health Organisation estimates around ~500,000 people are killed each year, with ~250 million infected. The disease is caused by infection with Plasmodium parasites spread through the bites of infected Anopheles mosquitoes.
- Location
- Manchester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Birmingham
About the Project Antimicrobial resistance (AMR) is a major crisis for human medicine. Globally, untreatable bacterial infections are increasing, leaving limited treatment options. Gram-negative Enterobacteriaceae e.g. Klebsiella pneumoniae with carbapenem resistance are classified as critical priorities by the WHO. An important characteristic of bacteria is their ability to share genetic information, including AMR genes, via mobile-genetic elements such as plasmids.
- Location
- Birmingham, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Nottingham
About the Project (scientific summary; context of wider project; lab environment; research consortium involvement; research centres; training opportunities; techniques) Left–right asymmetry (chirality) in land snails has long served as a model for understanding developmental evolution, but on São Tomé and Príncipe it intersects with an urgent conservation challenge.
- Location
- Nottingham, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Leicester
About the Project Background/project proposal: Cancer is characterized by multi-cellular communities with complex interactions that shape disease progression, treatment responses, and patient survival [1]. Previous studies have revealed broad tumour microenvironment (TME) phenotypes across cancer types, such as T cell inflamed (“hot”) and T cell depleted (“cold”) subtypes [2].
- Location
- Leicester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
Garvan Institute of Medical Research
About the Project Project Description Alternative splicing (AS) is one of the most powerful mechanisms generating protein diversity in the human brain. Dysregulation of splicing is increasingly recognised as a major driver of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and hereditary spastic paraplegia (HSP).
- Location
- Sydney, Australia, Australia
- Deadline
- Year-round applications
- Funding
- Competition Funded PhD Project (Students Worldwide)
Bioinformatics
Imperial College London
About the Project This is a co-funded industry PhD studentship embedded in a collaborative partnership between Imperial College London and Agragene Inc., the company holding the pgSIT patent and leading its commercial development. Agricultural insect pests cause major crop losses worldwide and place pressure on food security.
- Location
- London, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Funded PhD Project (UK Students Only)
Bioinformatics
Imperial College London
About the Project The Mexican fruit fly, Anastrepha ludens (Mexfly), is an important invasive agricultural pest and a priority target for the development of precise, species-specific and environmentally responsible control strategies in the United States.
- Location
- London, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Funded PhD Project (UK Students Only)
Bioinformatics
University of Worcester
About the Project Demand for food production is increasing due to growing global population, reduced land availability for agriculture, concern over the effects of the environment on agriculture, and decreasing yield reliability because of climate change. We need to rise to this challenge and provide solutions to grow enough food in a sustainable way.
- Location
- Worcester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
The University of Manchester
About the Project Pancreatic Ductal Adenocarcinoma (PDAC), which develops from cells lining pancreas ducts, represents 95% of all pancreatic cancer cases. In the UK alone, PDAC is the 11th most common cancer with ~10,000 new cases diagnosed every year. It has abysmal life-expectancy with only 7% surviving the first five years[1]. PDAC death rates are constantly on the rise and it is projected to become the second most lethal cancer by 2030[2].
- Location
- Manchester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Nottingham
About the Project How do the environment and ecology interact with genetics and development to produce reproductive isolation between populations, ecotypes and species? Thanks to advances in gene sequencing and editing technologies, we are in a remarkable period of discovery about the genomic and developmental basis of adaptation and speciation and how this depends on the intricacies of ecology and environment.
- Location
- Nottingham, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of York
About the Project Lead supervisor: Dr Noemie Hamilton The student will be registered with the Department of Biology Our research interests are to dissect the mechanism of auto-inflammatory neurological disorders using zebrafish as an animal model. Leukodystrophies are devastating rare monogenic neurological diseases with patients presenting loss of white matter and severe developmental delays.
- Location
- York, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Leicester
About the Project Project: DNA methylation is a core epigenetic mechanism involved in regulating gene expression, mediating environmental responses, and potentially influencing genome evolution. However, the function of gene-body DNA methylation is debated. One hypothesis posits that gene-body methylation stabilizes gene expression by maintaining open chromatin structure.
- Location
- Leicester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Nottingham
About the Project Project Overview: This study aims to use high throughput sequencing technologies and molecular approaches to understand how RNA epitranscriptomic processes, i.e. the modification of RNA, contribute to susceptibility to human disorders of the brain.
- Location
- Nottingham, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Portsmouth
About the Project Applications are invited for a self-funded, 3 year full-time or 6 year part-time PhD project. The PhD will be based in the School of Electrical and Mechanical Engineering and will be supervised by Dr Roxane Bonithon and Professor Chris Louca .
- Location
- Portsmouth, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
King’s College London
About the Project Who are we? We are a vibrant, outward-looking, multi-disciplinary research group interested in understanding how genetic risk factors can impact on both susceptibility to infection and to autoimmune disease. We have a strong interest in comparing how genetic risk factors from different ancestries impact on risk of infection and in developing autoimmune disease.
- Location
- London, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Leicester
About the Project Project Summary Idiopathic Pulmonary Fibrosis (IPF) is a progressive and fatal lung disease affecting approximately 50 per 100,000 individuals in the UK. Despite recent therapeutic advances, prognosis remains poor, with a median survival of three years and limited treatment options. Genetic studies have revealed several risk loci, yet common genetic variants explain only about 19% of disease heritability.
- Location
- Leicester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Leicester
About the Project Second Supervisor: Prof. Sheela Jayaraman, Health and Medical Sciences/BDI/Medicine/ Translation Medical Sciences/Centre Cancer Science, University of Nottingham Additional Supervisor: Prof.
- Location
- Leicester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Nottingham
About the Project Who we are looking for We are seeking a PhD student who is motivated by the process of scientific discovery and the opportunity to identify novel targets for anti-cancer therapies. A successful candidate will have good background knowledge of molecular and cell biology and will be comfortable with computational analyses.
- Location
- Nottingham, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Leicester
About the Project Project: Cyclin-dependent kinases (CDKs) are protein kinases performing essential functions by regulating cell cycle and RNA polymerase II transcription of protein-coding and non-coding genes. Each CDK requires an interaction with a specific cyclin partner for switching on their kinase activity. Mutations and dysregulation of different CDKs and associated cyclins have been linked to multiple cancers.
- Location
- Leicester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of York
About the Project Lead supervisor: Dr Simon Baker Co-supervisors: Prof Will Brackenbury The student will be registered with the Department of Biology Background BK polyomavirus is a ubiquitous infection that nearly everyone acquires during childhood. Once we have been infected with BK virus, it establishes a persistent infection of the kidney, where it is largely kept under control by the immune system.
- Location
- York, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
Durham University
About the Project Climate change brings many challenges for the planet’s plants and one of these is the vulnerability caused by erratic temperatures. Many plants, including major crops, prepare for winter through a process called cold acclimation . In this process, plants respond to the cooler temperatures that prevail in the autumn, by making changes that equip them with resilience against subsequent freezing conditions in winter.
- Location
- Durham, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Leicester
About the Project Telomeres are protein bound stretches of repetitive DNA at the end of linear chromosomes that prevent the end of the DNA being incorrectly recognised as a DNA break. The telomere cannot be fully replicated during cell division leading to a loss in length with each cycle. When a critically short length is reached the cell enters replicative senescence.
- Location
- Leicester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Leicester
About the Project Second Supervisor: Professor Sue Francis, Sir Peter Mansfield Imaging Centre, University of Nottingham Additional Supervisors: Dr Richard Allen, University of Leicester / Dr Eleanor Cox, University of Nottingham Fibrosis (scarring) is the natural process of wound-healing, the body’s response to insult and injury.
- Location
- Leicester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
Royal Holloway, University of London
About the Project Ketogenic diets, involving restricted carbohydrate and high fat consumption, have been proposed to increase skeletal muscle strength, with likely impacts on professional sports performance. In addition, these diets may provide a potential avenue for the treatment of skeletal muscle loss in old age (sarcopenia).
- Location
- Egham, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Birmingham
About the Project The tragedy of adverse drug reaction (ADRs) is synonymous with thalidomide yet in the context of mental health (MH) patients, intolerable side effects of psychiatric medication, leading to poor concordance, with the likelihood of further deterioration and possible involuntary treatment, is emerging as a very serious health issue.
- Location
- Birmingham, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Leicester
About the Project The human visual system depends on the precise interplay between retinal structure and neural processing to support high-acuity vision. Understanding this structure–function relationship is central to neuroscience and vision science, yet remains poorly characterised in humans at a population level.
- Location
- Leicester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Leicester
About the Project Background T-cell lymphomas are rare but highly aggressive blood cancers. Despite advances in cancer research, outcomes for patients with these diseases have seen little improvement in the past 30 years. New treatment strategies are urgently needed but to realise precision medicine strategies, we first need precision diagnostics and tools that can track disease risk and treatment response in real time.
- Location
- Leicester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Dundee
About the Project DNA replication is required for successful cell fate transitions across diverse physiological, experimental, and pathological contexts, involving factors often deregulated in human cancer and intellectual disabilities. The underlying mechanisms are fundamental for our understanding of organ homeostasis but are poorly understood.
- Location
- Dundee, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Dundee
About the Project Microglia are the resident immune cells of the central nervous system, responsible for responding to infection and damage in a protective manner. In Alzheimer’s Disease, microglia responses are dysregulated, leading to chronic inflammation and failure to protect the brain from neurodegeneration.
- Location
- Dundee, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Dundee
About the Project Microglia are the major innate immune cells in the central nervous system and are required for the response to invading pathogens, removal of damaged or apoptotic cells and also contributing to neuronal development via synaptic pruning. To achieve these diverse functions, microglia must be able to adopt a spectrum of pro- and anti-inflammatory phenotypes.
- Location
- Dundee, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Sheffield
About the Project The leading cause of death globally is cardiovascular disease (CVD), according to the World Health Organisation. Atherosclerosis is the underlying cause of most of these deaths. It is a long-term disease of the blood vessels, where fat and inflammation builds up in the walls of arteries to form a plaque that can lead to heart attack and stroke. Smooth muscle cells (SMCs) play a key role in preventing rupture of these plaques.
- Location
- Sheffield, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of York
About the Project Lead supervisor: Dr Andrew Holding The student will be registered with the Department of Biology The Holding Lab at the University of York develops and applies cutting-edge genomics, proteomics, and chemical biology technologies to explore how transcription factors and chromatin regulators control gene expression in response to cellular signals.
- Location
- York, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
The University of Manchester
About the Project Background : Psoriatic arthritis (PsA) is an inflammatory arthritis which causes joint inflammation, pain and resultant disability. PsA affects up to 30% of those with psoriasis (PSc). It is a genetically complex disease, characterised by environmental and genetic risk factors. Biologic drugs, such as TNF inhibitor (TNFi) drugs are prescribed to treat the disease.
- Location
- Manchester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Reading
About the Project Cancer is an evolutionary process. Cells in a tumour vary due to mutation, and so over many generations they adapt in response to both intrinsic selective pressures (such as anoxia) and extrinsic selective pressures (such as chemotherapy).
- Location
- Reading, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
The University of Manchester
About the Project Accurate genomic variant reporting is essential for rare disease diagnosis, yet scientific papers, clinical reports, and database submissions routinely contain erroneous variant descriptions and omit crucial clinical evidence such as ACMG scores and pathogenicity classifications. These gaps limit the findability of supporting evidence, reduce diagnostic yield, and add to the genomic medicine diagnostic odyssey.
- Location
- Manchester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Reading
About the Project The aim of this project is to research and develop the next generation of Internet of Things (IoT) connected wearable sensor technologies for applications in healthcare and physiotherapy. The project will investigate methods of sensing data from the body using wearable sensors fused with pervasive sensors in mobility aids and our homes. The sensor data can then be used to create new insights into healthcare, human motion and emotional states.
- Location
- Reading, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Reading
About the Project Prof. Rastall is interested in research in the area of prebiotic oligosaccharides, synbiotic combinations with probiotics and the impact of structure on the gut fermentation of carbohydrates. An opportunity is available for a self-funded PhD student to work on the potential of converting waste biomass into functional food ingredients. He is looking for a PhD student with skills in enzyme biotechnology, microbiology and/or carbohydrate analysis.
- Location
- Reading, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Birmingham
About the Project RNA biology is emerging as a central theme in neurodegenerative disease. In ALS, FTD and related disorders, disruption of RNA processing, RNA-binding proteins and RNA-protein assemblies can lead to harmful aggregates and loss of cellular resilience. This PhD project will investigate how the conserved RNA helicase UPF1 helps cells process, release and protect messenger RNAs, and how failure of this system may contribute to stress and neurodegeneration.
- Location
- Birmingham, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
The University of Manchester
About the Project The human spinal cord (SC) has limited regenerative capacity, and no effective therapies exist to restore function after spinal cord injury (SCI), resulting in severe disability and low quality of life and life-expectancy. In non-regenerative species, damaged axons fail to regrow, and neural stem/progenitor cell (NSPC) proliferation primarily contributes to scar formation.
- Location
- Manchester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Leicester
About the Project Genetic studies of disease primarily look at risk by comparing cases (with the disease) to controls. There is now great interest in investigating the potential role of genomic data on progression and prognosis for those living with disease. A recent paper has highlighted the limited overlap between genetic signals between studies on risk and mortality 1 .
- Location
- Leicester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Birmingham
About the Project In virtually all living organisms, mutations of genomic DNA allow the generation of new traits that, if positively selected, drive adaptation to changing environments and contribute to evolution. In most multicellular organisms, these DNA mutations are propagated only if passed to next generations by creating a mutated progeny. In addition, intra-organism DNA changes also occur and are known as somatic mutations.
- Location
- Birmingham, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Leicester
About the Project Meiotic recombination plays a central role in generating DNA diversity, which in turn provides the capacity for a species to evolve. In humans, most attention has been paid to characterising meiotic crossover (CO) as this is essential for the correct segregation of homologous chromosomes and therefore avoidance of aneuploidy; it is also readily detectable.
- Location
- Leicester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Sheffield
About the Project Cardiovascular diseases such as atherosclerosis and aortic aneurysms develop when communication between cells in the blood vessel wall becomes disrupted. This PhD project will investigate how endothelial cells, which line the inside of blood vessels and sense blood flow, communicate with vascular smooth muscle cells, which provide strength and structure to the vessel wall. A key focus of the project is polycystin-1, encoded by the PKD1 gene.
- Location
- Sheffield, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Sheffield
About the Project Electroencephalogram (EEG) is a non-invasive technique commonly used to measure brain activity. In this project, we aim at using EEG Biofeedback (brain-computer interface (BCI)) for improving cognitive performance (e.g. attention, memory, error awareness) in different groups of people including healthy young adults, elderly and patients with cognitive disabilities.
- Location
- Sheffield, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Birmingham
About the Project We are seeking talented, motivated students with a passion for research in Acute Respiratory Distress Syndrome to join Dr Rahul Mahida’s team in the Institute of Inflammation and Ageing at the University of Birmingham ( https://www.birmingham.ac.uk/staff/profiles/inflammation-ageing/mahida-rahul.aspx ).
- Location
- Birmingham, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
The University of Manchester
About the Project Diagnosing inflammatory arthritis promptly and accurately can be challenging when antibody blood tests are normal (“seronegative”) and clinical features overlap. Seronegative rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis and polymyalgia rheumatica can present with similar symptoms but require different treatment strategies. Misclassification can lead to delayed effective treatment, prolonged glucocorticoid exposure and poorer outcomes.
- Location
- Manchester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
University of Bristol
About the Project The glycocalyx is a protective gel-like layer that lines the endothelial cells of all blood vessels. Glomeruli are the microvessels in the kidney that filter blood (retaining larger proteins, such as albumin) and are lined with glycocalyx. 1 Glomerular glycocalyx damage is associated with low-level albuminuria (progressing to more severe albuminuria) found in individuals with type 1 & 2 diabetes who are also known to have reduced systemic glycocalyx volume.
- Location
- Bristol, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only
Bioinformatics
The University of Manchester
About the Project Most people at high genetic risk of immune-mediated inflammatory disease never develop disease, while some develop disease despite apparently low inherited risk. These “genetically discordant” individuals may reveal mechanisms of disease protection, resilience and susceptibility that are missed by conventional genetic risk prediction.
- Location
- Manchester, United Kingdom, United Kingdom
- Deadline
- Year-round applications
- Funding
- Self-Funded PhD Students Only