Mapping Spatal Plastcity Dynamics in Colorectal Cancer

About the project

About the Project The Cell Communication Lab at the UCL Cancer Institute , led by Prof. Chris Tape, is dedicated to understanding how cancer cells communicate, adapt, and evolve within complex tumour environments. Our research combines cutting-edge experimental and computational approaches to investigate fundamental questions in cancer biology, with a particular focus on cancer cell plasticity and treatment resistance. About the role This fully funded four-year PhD project will investigate how cancer cell plasticity varies across different regions of colorectal tumours. The successful candidate will explore a fundamental question in cancer biology: whether all tumour cells possess the ability to switch between drug-sensitive and drug-resistant states. You will establish and analyse patient-derived organoid models from multiple tumour regions, perform functional perturbation experiments, and study responses to chemotherapy. In parallel, you will use spatial transcriptomic technologies and advanced computational approaches to map plasticity dynamics within tumour tissue. Throughout the studentship, you will receive training in a range of state-of-the-art technologies, including organoid culture, single-cell mass cytometry, spatial transcriptomics, and high-dimensional data analysis. Working at the interface of discovery science and clinical research, you will collaborate with leading researchers across UCL and an international network of scientists within the REWIRE-CAN consortium. How to Apply Submit the following by 24 th October 2026- (using the apply button.) CV including: Contact details of two referees (one academic). A short statement explaining how your experience aligns with the project and person specification. Academic transcripts and certificates (PDF format). Include official English translations if applicable. About you You are a highly motivated and curious scientist with a strong interest in cancer biology and a desire to address important biomedical research questions. You enjoy problem-solving, are resilient when faced with experimental challenges, and are excited by the opportunity to work in a collaborative team-science environment. You will have, or be expecting to achieve, a First or Upper Second Class degree (or equivalent) in a relevant subject. A strong background in cell biology or cancer biology is desirable, along with an enthusiasm for learning new experimental and computational techniques. Experience in complex cell culture systems, such as organoids, single-cell technologies, or data analysis using Python and/or R would be advantageous. Most importantly, you will be passionate about advancing our understanding of cancer biology through innovative research and collaborative working. What we offer This is a full time fully funded 4year PhD studentship , successful candidates will receive a non-taxable annual stipend of £27,800pa covering tuition fees at Home rate and meet UCL PhD admissions criteria. Further information Recruiter email: martin.holland@ucl.ac.uk / a.vargas-sotelo@ucl.ac.uk Adcourier username: martin.holland@UCL.office.universitycollegelondon Application URL: Apply now Reference: B02-11314 Type: Temporary Position: Full Time PhD Studentship- Mapping Spatial Plasticity Dynamics Location: England Industry: Science and Research

Research areas