[School of Natural Sciences PhD Scholarships] Modelling chemical warfare and its evolution in microbial communities

About the project

About the Project Many bacteria use sophisticated weaponry – including small molecule antimicrobials, protein syringes, hole-punching nanomachines and weaponised viruses – to compete with rival microorganisms for space and resources. As well as their roles in shaping microbial communities and infections, these antimicrobials hold immense biotechnological potential for addressing pressing global challenges, including antimicrobial resistance (AMR), biocontrol, and microbiome engineering. But when and why are these aggressive strategies actually favoured in bacteria? Which strains do we expect to be armed to the proverbial hilt? This PhD project will address this question by developing sophisticated computer models of chemical between bacteria, building on our past work. We will use these models to simulate interactions between unarmed, single- or multi-weapon strategists, and thereby understand the factors that most strongly favour or disfavour large arsenals across a wide range of simulated ecologies. Overall, this project will accelerate the search for different antimicrobial natural product classes by informing on the ecologies most likely to favour their use. This project is expected to start in September 2027. Before you apply: We strongly recommend that you contact the supervisors for this project before you apply. How to apply: To be considered for this project you must complete a formal application through our online application portal. If you already have an applicant account this link will directly open an application for PhD School of Natural Sciences Scholarships . If you don’t already have an applicant account, please follow the instructions here . When applying, please specify the full title and supervisor/s of the project, details of your previous study, and names and contact details of two referees. You must also upload a Supporting Statement describing your motivation to apply to the project, your CV and transcripts of awarded and in-progress university qualifications . Please note late or incomplete applications will not be considered. Equality, diversity and inclusion are fundamental to the success of The University of Manchester and central to all our activities. A diverse research community strengthens creativity, productivity and quality, while increasing the societal and economic impact of our work. We welcome applicants from all career paths, backgrounds and sections of the community, regardless of age, disability, ethnicity, gender, gender expression, sexual orientation or transgender status. We welcome applications from candidates returning to study after a career break or experience in other roles. Flexible study arrangements may be available, including part-time study at 50%, 60% or 80%, subject to the requirements of the project and funder. Eligibility : The standard academic entry requirement for this PhD is an upper second-class (2:1) honours degree (or international equivalent) in Engineering, Physics, Systems biology, Mathematics, Bioinformatics OR any upper-second class (2:1) honours degree and a Master’s degree at merit (or international equivalent) in Engineering, Physics, Systems biology, Mathematics, Bioinformatics. Previous research experience in at least one major programming language and quantitative modelling is desirable. This project will remain open until filled. If your application is submitted by 1 st November 2026, you can expect a decision by 18 th December 2026. If your application is submitted by 15 th January 2027, you can expect a decision by 30 th March 2027. Self or externally funded students can also be considered for this project. FSESoNS

Research areas