[School of Natural Sciences PhD Scholarships] Biosynthesis of Designer SQDG As a Novel Bioactive Agent

About the project

About the Project RAC1 is a small GTPase protein that functions as a key signaling node downstream of various microenvironmental signaling pathways. RAC1B, a RAC1 variant with an extra19 amino acid insert, is overexpressed in various cancers, including breast, colorectal and lung cancers. This project will seek to unravel the differences in signalling mechanism of RAC1 and RAC1B leveraging structural biology, high-throughput 19F NMR, advanced molecular simulation, combined with the design, synthesis and biophysical evaluation of small chemical tool compounds that bind tightly and selectively to RAC1B over RAC1. Thus, this interdisciplinary project combines computational, chemical and biophysical aspects to offer an exciting research opportunity at the experimental medicine and enzymology interface. This project aligns with UKRI skills priorities by fostering interdisciplinary expertise at the intersection of data science, human health, and biology. The student will gain proficiency in structural biology, high-performance computing, and molecular modeling, applying advanced algorithms to analyse complex biological data. These computational and quantitative skills are essential for modern health research and align with the MRC’s emphasis on developing quantitative skills and use data-driven approaches to understanding disease. The student will also develop expertise in analytical biophysics, organic synthesis, and cell biology, ensuring a multidisciplinary skill set that bridges computational and experimental sciences. This discipline-spanning approach not only enhances UK research competitiveness but also equips the student with versatile skills for diverse career paths. This project is expected to start in September 2027. Before you apply: We strongly recommend that you contact the supervisors for this project before you apply. How to apply: To be considered for this project you must complete a formal application through our online application portal. If you already have an applicant account this link will directly open an application for PhD School of Natural Sciences Scholarships . If you don’t already have an applicant account, please follow the instructions here . When applying, please specify the full title and supervisor/s of the project, details of your previous study, and names and contact details of two referees. You must also upload a Supporting Statement describing your motivation to apply to the project, your CV and transcripts of awarded and in-progress university qualifications . Please note late or incomplete applications will not be considered. Equality, diversity and inclusion are fundamental to the success of The University of Manchester and central to all our activities. A diverse research community strengthens creativity, productivity and quality, while increasing the societal and economic impact of our work. We welcome applicants from all career paths, backgrounds and sections of the community, regardless of age, disability, ethnicity, gender, gender expression, sexual orientation or transgender status. We welcome applications from candidates returning to study after a career break or experience in other roles. Flexible study arrangements may be available, including part-time study at 50%, 60% or 80%, subject to the requirements of the project and funder. Eligibility : The standard academic entry requirement for this PhD is an upper second-class (2:1) honours degree (or international equivalent) in Chemistry or Biochemistry OR any upper-second class (2:1) honours degree and a Master’s degree at merit (or international equivalent) in Chemistry or Biochemistry. Previous research experience in structural biology, organic synthesis, or computational chemistry is desirable. This project will remain open until filled. If your application is submitted by 1 st November 2026, you can expect a decision by 18 th December 2026. If your application is submitted by 15 th January 2027, you can expect a decision by 30 th March 2027. Self or externally funded students can also be considered for this project. FSESoNS

Research areas