Mitochondrial Genetic Determinants of Multiple Sclerosis
Not stated
- Funding
- Competition Funded PhD Project (Students Worldwide)
- Application deadline
- 8 December 2026
About the project
About the Project Summary This project is focused on establishing the role of mitochondrial genetic variants in determining the outcome of MS. Project Aims Genome-Wide Association (GWAS) in multiple sclerosis have identified over 200 autosomal genetic variants that influence the disease but have not systematically considered the role of the mitochondrial genome, despite the fact that it is well established that pathogenic mitochondrial variants, such as those causing Leber’s hereditary optic neuropathy (LHON), can influence the outcome of the disease. In this project we will use a specifically designed mitochondrial variant calling pipeline (PMID: 34002094) to analyse whole genome sequence data (30x) from 3,800 patients with multiple sclerosis and correlate observed common variation with clinical course. (PhD or MPhil)