Using genomics & bioinformatics to decipher immunity

About the project

About the Project Group Leader: Professor Sarah Teichmann ( Teichmann Group ) Keywords: Spatial transcriptomics of the heart Research Summary The Teichmann lab strives to understand how humans are built from our most basic building blocks: our cells. They study how cells are different based on the genes they switch on, their physical location within our organs, how they communicate and how these things influence what they do. Understanding our cells not only allows us to understand how we ‘work’, but how things go wrong in disease and may provide new leads to improve human health. They have a particular interest in the immune system in health and disease. Many of our group are experts in data analysis, building new computational tools to drive our research, and that of the community, forwards. They are a key member of the Human Cell Atlas (HCA) project, of which Sarah Teichmann is co-chair. More information on the HCA can be found here. Research Focus Sarah Teichmann is one of the co-founders of the Human Cell Atlas, a global initiative bringing together thousands of scientists to ‘create a comprehensive reference map of the types and properties of all human cells, the fundamental unit of life, as a basis for understanding, diagnosing, monitoring and treating health and disease’ (HCA mission statement). The Teichmann Group studies the composition of human tissues in both healthy and disease states using single cell and spatial genomics, often using cutting-edge methods. Many of the group members have a deep interest in immunology, including tissue-resident immune cells and cross tissue studies. They study the healthy human immune system, how it develops during pregnancy, and how it is modified in disease. The Teichmann Group is also world-leading in computational analysis and method development. The majority of their staff are ‘dry-lab’ scientists, working on data analysis, new methods and data portals. Their greatest strength is their people. The members come from around the world and a myriad of different disciplines, working together to push scientific research and technology development. From those just starting out to world-leaders in their field, they are always looking for the best and the brightest to join the team. To Apply: We encourage prospective PhD students to reach out directly to Professor Teichmann, sat1003@cam.ac.uk to discuss potential projects and supervision. Applicants must secure the support of a Supervisor within a laboratory before submitting an application . Please contact the project Supervisor(s) to discuss potential supervision, proposed research project and funding options, which should then be used to write your formal application. Applications will be submitted to the ' PhD in Stem Cell Biology ' and full course details can be found at https://www.postgraduate.study.cam.ac.uk/courses/directory/blscpdscp

Research areas