Cellular decision making in normal and leukaemic blood stem cells

About the project

About the Project Group Leader: Professor Bertie Göttgens ( Göttgens Group ) Research Summary Blood stem cells maintain the lifelong production of all blood cell types. This depends on finely tuned control systems which can fail as we age or go wrong and lead to disease (leukaemia). The Göttgens Group uses experimental and computational approaches to discover how these control systems work and how their disruption leads to disease. Research Focus Combining experimental and computational approaches, the Göttgens group has mapped the gene regulatory networks that control blood stem cells and revealed how their disruption contributes to leukaemia. More recently, the group has harnessed single-cell and time-series genomics to build dynamic models of blood production, revealing how stem cells adapt during development, ageing and disease. Current research focuses on: (i) early blood development from pluripotent cells (ii) mechanisms of cellular decision making in blood stem and progenitor cells (iii) functional consequences of leukaemogenic mutations (iv) computational modelling of normal and perturbed haematopoiesis To Apply: We encourage prospective PhD students to reach out directly to Professor Göttgens, bg200@cam.ac.uk to discuss potential projects and supervision. Applicants must secure the support of a Supervisor within a laboratory before submitting an application . Please contact the project Supervisor(s) to discuss potential supervision, proposed research project and funding options, which should then be used to write your formal application. Applications will be submitted to the ' PhD in Stem Cell Biology ' and full course details can be found at https://www.postgraduate.study.cam.ac.uk/courses/directory/blscpdscp

Research areas