Mathematical Modelling of Neurodegenerative Tauopathies - from Systems to Clinical Impact

About the project

About the Project Summary This project will build on work within the lab developing in silico mathematical models of neurodegenerative disorders associated with the tau protein. The model is validated against real-world data from our cohort of people with Progressive Supranuclear Palsy, Corticobasal Syndrome, and Frontotemporal Dementia using neuroimaging and neuropathology data. This project will focus on developing the models to make predictions of clinical severity and progression, including capturing the heterogeneity of clinical presentations. This will lead to a disease model suitable for evaluating and predicting the effect of novel disease modifying treatments on clinical presentation and progression. Project Aims Integrate clinical outcomes into predictions from generative models of neurodegenerative tauopathies. Test model predictions in the evaluation of potential disease modifying treatment trials. Neurodegeneration Informatics Laboratory - Home How to Apply; If you are interested in this project, please go to the University pages and apply via the online portal; PhD https://www.postgraduate.study.cam.ac.uk/courses/directory/cvcnpdpcn/apply Research MPhil https://www.postgraduate.study.cam.ac.uk/courses/directory/cvcnmpmds/apply

Research areas