Development of new-to-nature enzymatic reactivity for applications in organic synthesis.

About the project

About the Project The Mateo Sanchez Lab, located in the Department of Chemistry at the University of Cambridge, works at the interface of chemistry and biology. One of our research aims is to use enzymatic catalysis to create new reactivity profiles, enabling chemical transformations that are challenging or inaccessible using conventional synthetic methodologies. The proposed PhD project will focus on the discovery and development of new-to-nature reactivity using engineered enzymes. A major component of the project will involve the synthesis of substrates using traditional synthetic chemistry, screening campaigns to identify and optimise enzymatic activity, structural characterisation by NMR, and analysis using chiral HPLC and GC. The expected starting date would be around 1st of October 2027 We are looking for a candidate with an excellent academic record (first-class honours, above 8.5 on a 10-point scale, or above 3.7 on a 4-point scale CGPA) and a strong background in chemistry, with particular emphasis on organic and asymmetric chemistry. Previous research experience in organic synthesis will be highly advantageous. An MPhil, MSc, or equivalent research experience in a relevant field is strongly recommended. Most importantly, we are seeking an individual who is intellectually curious, enthusiastic about interdisciplinary research, and motivated to develop new experimental approaches to challenging chemical problems. The successful candidate will be expected to contribute creatively to the development of the project, take ownership of their research, and work effectively as part of a collaborative and interdisciplinary team. They will be encouraged to develop their own ideas and research directions while contributing to the broader research activities of the laboratory. Excellent communication skills, both written and oral, are essential, as the candidate will be expected to present their findings clearly through group meetings and seminars. This PhD provides an exciting opportunity to develop cutting-edge expertise at the interface of organic chemistry, photocatalysis, enzyme engineering, and high-throughput screening. The project will provide comprehensive training in modern synthetic chemistry, biocatalysis, protein engineering, photocatalysis, and high-throughput screening (HTS). For more information about our research, laboratory environment, and research philosophy, please visit the Mateo Sanchez Lab website ( https://www.mateosanchezlab.com/ ). Application Instructions To be considered, please submit the following materials: A full curriculum vitae (CV), including your academic transcripts. A cover letter highlighting your research background and the areas of our work that interest you. Names and contact information for two academic references. Please email your application materials to: mis40@cam.ac.uk

Research areas