Disease Mechanisms: From Phenotypic Discovery to New Therapeutic Targets
Not stated
- Funding
- Self-Funded PhD Students Only
- Application deadline
- Year-round applications
About the project
About the Project Projects in this direction will investigate molecular mechanisms that drive major human diseases and identify new therapeutic targets. Research may begin with disease-associated phenotypes, endogenous metabolites, candidate genes or pathways identified from patient samples, or findings from multi-omics analyses, and will integrate these observations with mechanistic biology using primary cells, engineered cell lines, organoids and animal models. Depending on the research question, students may use transcriptomics, proteomics, metabolomics, high-content imaging, genetic perturbation and small-molecule probes to identify and validate causal mechanisms. Candidate pathways will be investigated through protein-interaction studies, biochemical reconstitution, subcellular localisation, pathway analysis, mouse models and cell-type-specific genetics. Projects may focus on fibrosis, cancer, inflammatory, metabolic or cardiovascular diseases. Applicants from biomedical sciences, molecular biology, medicine, pharmacology, bioinformatics and chemistry are welcome. Competitive scholarships are available. Candidates must apply separately for scholarship support. Funding is not guaranteed and is awarded based on academic merit. Principal Investigator: Professor Xiaoguang Lei Email: xglei@pku.edu.cn Telephone: +86-10-6276-0292 Laboratory webpage: https://www.chem.pku.edu.cn/leigroup/