AI-Enhanced Immersive Gamification for Learning Molecular and Structural Biology in Disease: Design, Implementation, and Educational Evaluation

About the project

About the Project This PhD project explores how Artificial Intelligence (AI), Virtual and Augmented Reality (VR/AR), and gamification can transform the teaching of complex biomedical concepts, particularly the molecular and structural mechanisms underlying human disease. Traditional teaching often relies on static diagrams or two-dimensional images, which struggle to convey the dynamic, three-dimensional interactions between macromolecules. This research will design and evaluate an interactive VR/AR learning environment that enables students to explore molecular and structural biology in realistic 3D contexts, guided by AI feedback and gamified challenges. Using Unity or Unreal Engine, the student will create immersive models of key molecular processes, such as receptor–ligand binding, enzyme catalysis, protein folding, and oncogenic mutation, based on the Protein Data Bank. AI technologies, including natural-language feedback agents, adaptive reinforcement learning, and learning analytics, will personalise the learner’s pathway and provide real-time formative assessment. Gamification principles such as narrative framing, level progression, and reward systems will sustain engagement and foster problem-solving. Educational design will be grounded in constructivist learning theory, cognitive load management, and self-determination theory to ensure that technological innovation enhances learning. The evaluation strategy will use a mixed-methods approach, combining pre- and post-tests, behavioural analytics, and interviews to measure conceptual gains, spatial reasoning, and engagement. Comparisons will be made with conventional teaching and non-adaptive digital approaches to assess impact and scalability. Expected outcomes include a functional prototype of an AI-driven immersive gamified platform, empirical data on its educational value, and design principles for curriculum integration. The successful candidate will develop interdisciplinary expertise spanning molecular biology, educational technology, and AI, gaining experience in software development, learning design and pedagogical research. The project offers opportunities for collaboration with biomedical educators and technologists, and for publication and conference presentation. Eligibility Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject. Candidates with experience in molecular/structural biology with an interest in AI/XR and are encouraged to apply. Before you Apply Applicants must make direct contact with preferred supervisors before applying. It is your responsibility to make arrangements to meet with potential supervisors, prior to submitting a formal online application. How to Apply To be considered for this project you MUST submit a formal online application form – on the application form select PhD Biochemistry Programme. Full details on how to apply can be found on the Website: How to apply for postgraduate research at The University of Manchester If you have any queries regarding making an application please contact our admissions team FBMH.doctoralacademy.admissions@manchester.ac.uk Equality, Diversity and Inclusion Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website: Equality, diversity and inclusion (EDI | Postgraduate Research | Biology, Medicine and Health | University of Manchester

Research areas