Investigating cellular mechanisms of tissue homeostatis and fibrosis using omics approaches
Not stated
- Funding
- Funded PhD Project (UK Students Only)
- Application deadline
- 18 October 2026
About the project
About the Project Understanding how cells maintain tissue health or trigger irreversible decline is a frontier challenge in biomedical science. Using lung fibrosis as a primary disease model, this project investigates the core molecular networks controlling cellular fate, tissue regeneration, and scarring. This is a laboratory-based project perfectly suited for an ambitious experimentalist eager to master next-generation workflows. Working within a dynamic, multi-disciplinary team, you will manage and drive laboratory models, utilizing mammalian cell culture (including primary and stem/progenitor cell lines) to model tissue behaviour. You will gain hands-on expertise in cutting-edge molecular biology assays, including Next-Generation Sequencing (NGS) library preparation, and multi-omics workflows (ATAC-seq and RNA-seq). While the project is anchored in respiratory biology, the underlying cellular mechanisms link closely to broader tissue-remodeling projects within the lab, offering a highly collaborative environment. For candidates interested in a hybrid skillset, there is an excellent opportunity to learn computational biology tools. You will be supported by tailored training to analyze your own multi-omics datasets, positioning you at the forefront of modern, data-driven cell biology. You will benefit from active co-supervision spanning basic research and clinical science across Southampton Faculties (SoBS, Medicine). The Graduate School provides dedicated training in scientific writing, project management, and career development, alongside vibrant engagement with the wider respiratory and computational biology communities. How To Apply Please apply via the online portal and select: • Programme type: Research • Academic year: 2026/27 • If you will be full time or part time • Faculty: Environmental and Life Sciences Search for programme PhD Biological Sciences (7187) Please add the name of the supervisor in section 2 of the application. Applications should include: • your CV (resumé) • 2 academic references • degree transcripts/ certificates to date • English language qualification (if applicable) Faculty of Environmental and Life Sciences If you have a general question, email our Doctoral College ( doctoralcollege-admissions@soton.ac.uk ).