Advancing Functional MRS: Methodological Development for Dynamic Neurochemical Measurement

About the project

About the Project Project Overview Functional magnetic resonance spectroscopy (fMRS) is an emerging neuroimaging approach that measures rapid, task‑evoked changes in brain metabolites. Unlike traditional MRS, which provides a static snapshot of neurochemical composition, fMRS offers a unique window into dynamic neurochemical processes such as glutamate responses to sensory, cognitive, or emotional stimulation. This makes fMRS a powerful complement to established techniques like functional magnetic resonance imaging (fMRI), providing direct insight into neuronal function. Project Aim This PhD will develop and evaluate robust experimental and analytical frameworks for fMRS. Although fMRI methodology is well established, equivalent standards for fMRS remain underdeveloped. Experimental design choices (including task structure, timing, acquisition parameters, and analysis pipelines) have a profound impact on the reliability and interpretability of fMRS data. Establishing best‑practice paradigms is essential for advancing the field. Research Objectives The student will: · Optimise fMRS experimental designs to maximise sensitivity to dynamic metabolite changes · Develop and evaluate analysis pipelines beyond conventional approaches · Assess reproducibility and robustness across tasks, acquisition strategies, and quantification methods · Contribute methodological insights that will shape future fMRS research Training and Development You will receive comprehensive training in: · Advanced MRS and fMRS acquisition techniques · MRS quantification and modelling · Programming for neuroimaging analysis (e.g., MATLAB) · Experimental design and reproducible research practices This project is ideal for candidates with interests in neuroimaging, computational neuroscience, or methodological development. Prior experience in programming or MRI is helpful but not essential, full training will be provided. University of Reading: The University of Reading , located west of London, England, is ranked at 194 globally, according to the QS World University Rankings 2026. 98% of research at the University is of international standing (REF 2021, combining the University’s world leading, internationally excellent and internationally recognised submissions). The University’s main Whiteknights Campus is set in 120 hectares of beautiful, award-winning parkland, less than a 30-minute train ride to London Paddington and is approximately 30 miles from London Heathrow airport. During your PhD at the University of Reading, you will expand your research knowledge and skills, receiving specialist supervision. We also provide dedicated training in important transferable skills that can help support your career aspirations. If you need to develop your academic English skills before you start your studies, then the University has an excellent International Study and Language Institute which can help with this. Eligibility: · Applicants should have a strong master’s degree in neuroscience, neuroimaging, chemistry, biomedical engineering, computer science or a related discipline. · International applicants will also need to meet the University’s English Language requirements. We offer pre-sessional English courses that can help with meeting these requirements. The University of Reading is committed to a policy of equal opportunities and non-discriminatory treatment for all members of its community. How to apply: Submit an application for a PhD in Neuroscience via our online application system . Applicants should also provide a brief personal statement outlining their ambitions, intentions and passion for undertaking a PhD on this project. Further information: Insert link to department PhD webpage e.g. School of Biological Sciences PhD webpage Enquiries: Dr Tiffany Bell, email: t.bell@reading.ac.uk Please note that, where a candidate is successful in being awarded funding, this will be confirmed via a formal studentship award letter; this will be provided separately from any Offer of Admission and will be subject to standard checks for eligibility and other criteria.

Research areas