Enantioselective Cobalt-Catalysed Skeletal Rearrangements
Not stated
- Funding
- Self-Funded PhD Students Only
- Application deadline
- Year-round applications
About the project
About the Project Research in the Johnston group broadly focuses on the development of new catalytic reactions for (i) the streamlined synthesis of known small molecules or (ii) unprecedented access to novel building blocks, with potential applications in drug discovery and agrochemistry. To achieve these goals, we utilise and combine various areas of catalysis, including organocatalysis, photoredox catalysis, and base metal catalysis. A key aspect of our approach is ensuring that the reagents, catalysts, and solvents used are sustainable to meet the challenges of modern society. Moreover, to aid the fundamental understanding of these processes and accelerate reaction optimisation, a mechanism-guided approach will be adopted. Carbocations are common transient species known to participate in a wide range of useful rearrangement and addition reactions but in an unselective manner. In this project, we will employ a cobalt catalyst that, when bound to our starting material, can mimic the reactivity of these reactive intermediates. Unlike free carbocations, the proximity of the modifiable metal catalyst will enable us to control the enantioselectivity of the newly formed bonds. This strategy will harness the under-exploited potential of these reactive intermediates to produce a diverse collection of unique three-dimensional structures, vital to addressing future health and agricultural challenges. Informal enquiries regarding potential projects and funding options may be addressed to Dr Craig Johnston – email cpj3@st-andrews.ac.uk